Microdosimetric evaluations of boron compound efficacy

The ideal boron compound for application in boron neutron capture therapy (BNCT) should be selectively accumulated in tumor with concomitantly low concentrations in neighboring normal tissues and blood. As the presumed target of lethal radiation is the nucleus, an intracellular and, optimally, intranuclear localization of boron would be preferred. Boronated nucleosides, nucleotides, and DNA-intercalators have been synthesized in pursuit of this goal. This paper describes an approach to predict the relative biological effectiveness (RBE) values for such boron compounds. The results of this study may prove useful for future boron compound development for BNCT