Low-dose developmental bisphenol A exposure alters fatty acid metabolism in Fischer 344 rat offspring

Highlights: • Low-dose developmental exposure to BPA alters fatty acid composition in rats. • Increased fatty acid markers of SCD-1 activity in male offspring. • Decreased levels of linoleic acid, an essential fatty acid, in male offspring. • Increased body weight was found in female offspring. • The observed altered fatty acid composition may reflect insulin resistance. Bisphenol A (BPA) is an endocrine disruptor and also a suggested obesogen and metabolism-disrupting chemical. Accumulating data indicates that the fatty acid (FA) profile and their ratios in plasma and other metabolic tissues are associated with metabolic disorders. Stearoyl-CoA desaturase 1 (SCD-1) is a key regulator of lipid metabolism and its activity can be estimated by dividing the FA product by its precursor measured in blood or other tissues.