Published November 1998 | Version v1
Journal article Metadata-only

The distribution and excretion of nerve growth factor in mice

Creators

  • 1. CAMS and PUMC, Beijing (China). PUMC Hospital
  • 2. CAMS and PUMC, Beijing (China). Inst. of Basic Medicine Research

Description

Nerve growth factor (NGF) was iodolabelled with chloramine-T method and its distribution and excretion in mice were investigated. The results showed that the highest levels were found in superior cervical ganglia, thyroid, bile, kidneys and adrenals between 20-30 min after injection, and the peak time in most tissues was also found at 20-30 min. About 72.55% of the injected dose was excreted in stool and urine, among them 65.6% was excreted in urine and only 7.0% in stool within 72 h after intramuscular injection

Additional details

Publishing Information

Journal Title
Nuclear Techniques
Journal Volume
21
Journal Issue
11
Journal Page Range
p. 649-652
ISSN
0253-3219

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
30004058
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ADRENAL GLANDS; EXCRETION; FECES; IMPURITIES; IODINE 125; KIDNEYS; LABELLING; MICE; NERVE CELLS; RADIONUCLIDE KINETICS; THYROID; TISSUE DISTRIBUTION; URINE
Descriptors DEC
ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CLEARANCE; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPES; KINETICS; MAMMALS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; WASTES