The contents of glucocorticoid receptors in patients with nephritic syndrome and its clinical evaluation

This paper reports the contents of lymphocyte glucocorticoid receptors (GCR) in 48 patients with nephritic syndrome, using radioligand binding assay of receptors. The contents of GCR in patients with nephritic syndrome was 18936 ± 10097 binding sites/cell in adult and 9274 ± 3847 binding sites/cell in children. There was significant difference between them (p < 0.05). The contents of GCR in children and adult with nephritic syndrome were significantly higher than that in normal ones (p < 0.05). There were no significant difference between the contents of GCR in different sex and age groups (p > 0.05). The contents of GCR in patients with nephritic syndrome was significantly increased. This result suggested that contents of GCR in lymphocytes are correlated with nephritic syndrome, and the treatment of nephritic syndrome may be effective by hormonal therapy