Exploitation of Aspergillus flavus synthesized copper oxide nanoparticles as a novel medical agent

This study was designed to biosynthesize Aspergillus flavus copper oxide NPs (AFCuONPs) using extracellular fungous filtrate technique and evaluating its medical importance. AFCuONPs were successfully biosynthesized with average size of 32.4 nm and zeta potential of - 36 mV. They were fully characterized using FT-IR, UV-Vis spectrophotometry, and TEM. AFCuONPs cytotoxicity and bactericidal activity were evaluated against different cell lines and pathogenic bacteria, respectively. [^99mTc]Tc-AFCuONPs were radiosynthesized with high radiolabeling yield (93 ± 0.85%). In vivo biodistribution of [^99mTc]Tc-AFCuONPs in tumor-bearing mice model showed high tumor uptake. These results introduce AFCuONPs as a promising medical agent. (author)