Published November 2014 | Version v1
Journal article Metadata-only

3D-resolved targeting of photodynamic therapy using temporal focusing

Creators

  • 1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA (United States)
  • 2. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA (United States)
  • 3. Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA (United States)

Description

A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μg ml−1 and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules. (letter)

Availability note (English)

Available from http://dx.doi.org/10.1088/1612-2011/11/11/115605

Additional details

Identifiers

DOI
10.1088/1612-2011/11/11/115605;

Publishing Information

Journal Title
Laser physics letters (Internet)
Journal Volume
11
Journal Issue
11
Journal Page Range
[7 p.]
ISSN
1612-202X

INIS

Country of Publication
Germany
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
46051234
Subject category
S71: CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS;
Descriptors DEI
APOPTOSIS; APPROXIMATIONS; CELL CULTURES; ILLUMINANCE; NEOPLASMS; PHOTOSENSITIVITY; RESOLUTION; THERAPY; VISIBLE RADIATION
Descriptors DEC
CALCULATION METHODS; DISEASES; ELECTROMAGNETIC RADIATION; MEDICINE; RADIATIONS; SENSITIVITY