Published May 1975 | Version v1
Journal article Metadata-only

Sex-related differences in metabolism of 14C-acetate in response to steroid hormones by isolated rat hepatocytes

Creators

  • 1. Johns Hopkins Univ., Baltimore, Md. (USA). Dept. of Physiological Chemistry
  • 2. Johns Hopkins Univ., Baltimore, Md. (USA). Dept. of Medicine

Description

No differences were found in the basal rate of lipid synthesis from 14C-acetate in hepatocytes isolated from mature male and virgin female rats. Lipid biosynthesis was stimulated 22-43% in the female 60 min after the addition of gonadal steroids. This rapid response suggests that subtle differences exist in the enzyme profile controlling the pathways of lipid metabolism in male and female rats. This difference may have been determined genetically or acquired after a period of sex-dependent hormonal stimulation beginning with puberty. (orig.)

Abstract (German)

Grundsaetzlich wurden im Hinblick auf die Lipidsynthese aus 14C-Acetat keine Unterschiede zwischen isolierten Leberzellen von geschlechtsreifen maennlichen und noch nicht geschlechtsreifen weiblichen Ratten festgestellt. Die Lipid-Biosynthese steigerte sich bei den weiblichen Ratten innerhalb von 60 Minuten nach der Administration von Gonadensteroiden um 22-43%. Diese rasche Reaktion laesst vermuten, dass zwischen maennlichen und weiblichen Ratten minimale Unterschiede im Enzymprofil bestehen, das die Wege des Enzymstoffwechsels kontrolliert. Dieser Unterschied ist entweder genetisch festgelegt, oder er wird nach einer Periode geschlechtsabhaengiger hormoneller Stimulation erworben, die mit der beginnenden Geschlechtsreife einsetzt. (orig./AK)

Additional details

Identifiers

DOI
10.1055/s-0028-1093749;

Publishing Information

Journal Title
Hormone and Metabolic Research
Journal Volume
7
Journal Issue
03
Series
Horm. Metab. Res.
Journal Page Range
250-253
ISSN
0018-5043

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
7251481
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOSYNTHESIS; CARBON 14 COMPOUNDS; ESTRADIOL; FEMALE GENITALS; LIVER; MALE GENITALS; PROGESTERONE; RATS; REPRODUCTION; SEX; STEROIDS; STIMULATION; TESTOSTERONE; TRACER TECHNIQUES
Descriptors DEC
ANDROGENS; ANDROSTANES; ANIMALS; BODY; CARBON COMPOUNDS; DIGESTIVE SYSTEM; ESTRANES; ESTROGENS; GLANDS; HORMONES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; KETONES; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PREGNANES; RODENTS; STEROID HORMONES; SYNTHESIS; VERTEBRATES

Optional Information

Notes
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