Published October 1986 | Version v1
Journal article Metadata-only

Metabolism of 45Ti-labeled compounds: effect of ascorbic acid

Creators

  • 1. Tohoku Univ., Sendai (Japan). Faculty of Agriculture
  • 2. Tohoku Univ., Sendai (Japan). Cyclotron and Radioisotope Center
  • 3. Tohoku Univ., Sendai (Japan). School of Dentistry
  • 4. Tohoku Univ., Sendai (Japan). Inst. of Brain Diseases

Description

The preparation of 45Ti-ascorbate(AsA) is described and results presented for the tissue distribution of 45Ti-AsA and 45TiCl4 in rats and guinea pigs. The effect of low or high ascorbic acid intake on the tissue distribution is also investigated. Autoradiography of rat brain glioma was performed following administration of 45Ti-AsA; the results suggest that 45Ti-AsA may be a useful radiopharmaceutical for studying the blood-brain barrier. (UK)

Additional details

Publishing Information

Journal Title
J. Labelled Compd. Radiopharm.
Journal Volume
23
Journal Issue
10-12
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1360-1362
ISSN
0362-4803
CODEN
JLCRD

Conference

Title
6. international symposium on radiopharmaceutical chemistry.
Dates
29 Jun - 3 Jul 1986.
Place
Boston, MA (USA).

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
18082400
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ASCORBIC ACID; BRAIN; CHEMICAL PREPARATION; GUINEA PIGS; RADIOPHARMACEUTICALS; RATS; TISSUE DISTRIBUTION; TITANIUM 45
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NERVOUS SYSTEM; NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYNTHESIS; TITANIUM ISOTOPES; VERTEBRATES; VITAMINS