Research on the uptake of mercury 197 acetate in early bronchial cancers and on the variation of this uptake during drug therapy
Description
Mercury 197 was proposed as a means to analyze the behavior of early bronchial cancers, especially during drug treatment. This choice was based on four facts: a hyperfixation of mercury has already been demonstrated in malignant intrathoracic tumors; the use of mercury 197 in acetate form gives higher uptake rates than those observed with bichloride; because of its properties mercury 197 is easy to use in routine radioisotopic practice; mercury toxicity is negligible with the preparation employed. The work was performed in two stages: analysis of the uptake conditions for mercury 197 in acetate form in order to detect the factors which influence this uptake and to define its limits and advantages; on the basis of the above notions, use of mercury 197 as tracer to follow the development of bronchial tumors, the aim being to observe the tumor volume variation under drug treatment (the changes in uptake rate are analyzed and the numerical results obtained used to estimate the degree of efficiency of the treatment proposed, the moment of maximum result and the start of a new tumoral growth)
Abstract (French)
Le mercure 197 a ete propose comme moyen d'analyse du comportement des cancers bronchiques primitifs en particulier lors de leur chimiotherapie. Ce choix a ete justifie par quatre faits: la notion deja demontree d'une hyperfixation mercurielle au niveau des tumeurs intrathoraciques malignes; l'utilisation du mercure 197 sous forme d'acetate qui donne des taux de fixation superieurs a ceux notes avec la forme bichlorure; les proprietes du mercure 197 qui en font un agent facilement utilisable en pratique radioisotopique courante; la toxicite mercurielle infime avec la preparation employee. Le travail a ete conduit en deux temps: l'analyse des modalites de la fixation du mercure 197 sous forme d'acetate pour deceler les facteurs qui influencent cette fixation, preciser ses limites et indiquer son interet; l'utilisation des notions precedentes pour se servir du mercure 197 comme indicateur de l'evolution des tumeurs bronchiques; le but en est de saisir la variation du volume tumoral sous le coup de la chimiotherapie: on analyse donc les modifications du taux de fixation; on cherche a connaitre a l'aide de cette donnee numerique le degre d'efficacite du traitement propose, le moment du resultat maximal et l'amorce d'une nouvelle progression tumoraleAdditional details
Additional titles
- Original title (French)
- Etude de la fixation du mercure 197 sous forme d'acetate dans les cancers bronchiques primitifs et de l'evolution de cette fixation au cours de leur chimiotherapie
Publishing Information
- Imprint Pagination
- 85 p.
- Report number
- FRNC-TH--608
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 8303182
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Thesis, Non-conventional Literature
- Descriptors DEI
- ACETATES; BRONCHI; CARCINOMAS; DIAGNOSIS; MERCURY 197; SCINTISCANNING; UPTAKE
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; CARBOXYLIC ACID SALTS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; MERCURY ISOTOPES; NEOPLASMS; NUCLEAR MEDICINE; NUCLEI; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESPIRATORY SYSTEM
Optional Information
- Notes
- Copies available from Service de Documentation, CEN Saclay, B.P. No.2, 91190 Gif-sur-Yvette (France).