Published July 1982 | Version v1
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Investigations on the biological behaviour and the decorporation of 234Th in the rat

Creators

Description

In this work the biological behaviour of 234Th in the rat has been studied as function of mass, chemical form and route of entry. Further it was investigated if there is a correlation between iron metabolism and distribution of 234Th in the organism. The mobilization of 234Th with Ca- und Zn-DTPA as well as with other chelators and their combinations with DTPA has been determined as basis for acceptable therapeutic procedures for decorporation. (orig.)

Availability note (English)

MF available from INIS under the Report Number.

Abstract (German)

In der vorliegenden Arbeit wurde das biologische Verhalten von 234Th bei der Ratte in Abhaengigkeit von der injizierten Thoriummasse, der chemischen Form und dem Inkorporationsweg untersucht. Es wurde weiterhin untersucht, ob ein Zusammenhang besteht zwischen dem Eisenstoffwechsel und der Verteilung von 234Th im Organismus. Als Grundlage fuer die Erarbeitung geeigneter Therapieschemata zur Dekorporierung von 234Th wurde seine Mobilisierbarkeit durch Ca- und Zn-DTPA sowie durch andere Chelatbildner und ihren Kombinationen mit DTPA bestimmt. (orig.)

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Additional details

Additional titles

Original title (German)
Untersuchungen zum biologischen Verhalten und zur Dekorporation von

Publishing Information

Imprint Pagination
131 p.
Report number
KFK--3360

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
13713986
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Thesis
Descriptors DEI
BLOOD; CHELATING AGENTS; DTPA; EXCRETION; FECES; FEMALES; INJECTION; IRON 59; METABOLISM; ORGANS; RADIONUCLIDE KINETICS; RATS; RETENTION; THORIUM 234; URINE
Descriptors DEC
ACTINIDE NUCLEI; AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CLEARANCE; DAYS LIVING RADIOISOTOPES; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTAKE; INTERMEDIATE MASS NUCLEI; IRON ISOTOPES; ISOTOPES; KINETICS; MAMMALS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOISOTOPES; RODENTS; THORIUM ISOTOPES; VERTEBRATES; WASTES