Published 1995
| Version v1
Book
New avenues in hypoxic cell sensitization
Creators
- 1. Nanavati Hospital, Bombay (India). Division of Radiation Oncology
- 2. Bhabha Atomic Research Centre, Bombay (India). Radiation Biology and Biochemistry Division
Description
Hypoxic cells in tumors represent a population of cells that are resistant to radiotherapy. Bio-reductive agents like RSU 1069, RBU 6145 and EOg and vasoactive drugs in conjunction with hypoxic cell sensitizers are being evaluated as hypoxic cell cytotoxins. Chlorpromazine a membrane active drug and AK-2123- a nitrotriazole with a potential to deplete intracellular thiols induced vasoconstriction and sensitize hypoxic cells have stretched the boundaries of innovation. A preliminary experience with these drugs is discussed. 8 refs., 2 tabs., 2 figs
Additional details
Publishing Information
- Publisher
- Narosa Publishing House.
- Imprint Place
- New Delhi (India)
- ISBN
- 81-7319-055-0
- Imprint Title
- Radiobiological concepts in radiotherapy
- Imprint Pagination
- 213 p.
- Journal Page Range
- p. 120-126.
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 27031548
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ANOXIA; BIOLOGICAL RADIATION EFFECTS; CHLORPROMAZINE; DOSE-RESPONSE RELATIONSHIPS; NEOPLASMS; RADIATION DOSES; RADIOSENSITIZERS; RADIOTHERAPY; TOXICITY; TRIAZOLES; TUMOR CELLS
- Descriptors DEC
- AMINES; ANIMAL CELLS; AZINES; AZOLES; BIOLOGICAL EFFECTS; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASES; DRUGS; HETEROCYCLIC COMPOUNDS; HYPNOTICS AND SEDATIVES; MEDICINE; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PHENOTHIAZINES; PSYCHOTROPIC DRUGS; RADIATION EFFECTS; RESPONSE MODIFYING FACTORS; THERAPY; TRANQUILIZERS