Release of arachidonic acid from rat spleen lymphocytes after irradiation
- 1. Kievskij Gosudarstvennyj Univ., Kiev (Ukraine)
Description
After spleen lymphocytes incubation with 14 C-arachidonic acid 14 C label was found associated predominantly with phosphatidylethanolamine (PE) and phosphatidylcholine (PC). Addition of 0.5 mkM A23187 to the incubation media with 2mM Ca Cl2 caused a 4-fold increase in release of labeled free arachidonate in lymphocytes of the control animals. A dose-dependent increase in release of free arachidonate and membrane Ca2+ dependent phospholipase activity towards exogenous 2-14C-arachidonoyl-PE and -PC take place in a period 6-12 h after animal's irradiation in a doses 0.5 and 1.0 Gy. The maximum arachidonate release in 6 h following 1 Gy irradiation correlations with activation of more active phospholipase A2, hydrolising PE. Free arachidonate is supposed to be mobilized from different phospholipid pools, depending on the content of Ca2+ in the cells after irradiation
Additional details
Additional titles
- Original title (Russian)
- Высвобождение арахидоната из лимфоцитов селезенки крыс после облучения
Publishing Information
- Journal Title
- Ukrainskij Biokhimicheskij Zhurnal
- Journal Volume
- 66
- Journal Issue
- 3
- Journal Page Range
- p. 60-66.
- ISSN
- 0201-8470
- CODEN
- UBZHD4
INIS
- Country of Publication
- Ukraine
- Country of Input or Organization
- Ukraine
- INIS RN
- 26044597
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ARACHIDONIC ACID; BIOLOGICAL RADIATION EFFECTS; DOSE RATES; GAMMA RADIATION; LOW DOSE IRRADIATION; LYMPHOCYTES; PHOSPHOLIPIDS; RADIATION DOSES; RATS; SPLEEN CELLS; TIME DEPENDENCE; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; ESTERS; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; LEUKOCYTES; LIPIDS; MAMMALS; MATERIALS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC PHOSPHORUS COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES