Published February 1986 | Version v1
Journal article Metadata-only

Characteristics of benzodiazepine receptors in rats differing in predisposition to experimental alcoholism

Creators

  • 1. Academy of Medical Sciences of The USSR, Moscow

Description

This paper studies the number and affinity of benzodiazepine receptors for diazepam in the cerebral cortex and hippocampus of rats differently predisposed to the development of experimental alcoholism. Ethanol was injected once intraperitoneally, in a dose of 2.5 g/kg. Control animals received the same volume of physiological saline. Bound and free N-methyl-tritium-diazepam were separated by means of GF/B filters. The characteristics of benzodiazepine receptors are shown in rats differing in predisposition to the development of experimental alcoholism and in rats during voluntary chronic alcoholization. It is shown that weakening of functional acitivity of the GABA-benzodiazepam complex in animals predisposed to the development of experimental alcoholism is one of the neurochemical mechanisms of development of the abstinence syndrome

Additional details

Publishing Information

Journal Title
Bull. Exp. Biol. Med. (Engl. Transl.)
Journal Volume
100
Journal Issue
9
Series
Bull. Exp. Biol. Med. (Engl. Transl.).
Journal Page Range
1214-1216
ISSN
0007-4888
CODEN
BEXBA

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
18035961
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
BEHAVIOR; BIOLOGICAL EFFECTS; CEREBRAL CORTEX; CONDITIONED REFLEXES; ETHANOL; HIPPOCAMPUS; INTRAPERITONEAL INJECTION; PSYCHOTROPIC DRUGS; RADIORECEPTOR ASSAY; RATS; RECEPTORS; RETENTION; TRITIUM COMPOUNDS
Descriptors DEC
ALCOHOLS; ANIMALS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; CEREBRUM; DRUGS; HYDROGEN COMPOUNDS; HYDROXY COMPOUNDS; INJECTION; INTAKE; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; REFLEXES; RODENTS; TRACER TECHNIQUES; VERTEBRATES

Optional Information

Notes
Cover-to-cover translation of Byulleten' Ehksperimental'noj Biologii i Meditsiny (USSR).