Synthesis, Characterization and Study biological activity of some New Derivatives of Steroid analogs

The search includes a new series of hydrazide- hydrazone derivatives [12-14] as well as 1,3,4- Oxidiazole[7, 8] for steroid analog (methyl((5-pregnen-3β,17-diol-15-yl) thio) propanoate) were synthesized throw react ester group with Hydrazine Hydrate in presence DMF to obtained carbohydrazide derivative (4), then the 1,3,4-Oxodiazole are prepared by interaction Benzoic Acid substituted with steroid (4) in presence Phosphorous Oxy Chloride as catalyst. while Hydrazide-hydrazone are prepared by react the steroid (4) with aromatic aldehydes or ketone by catalyzes HOAc. Structures of all the newly synthesized compounds have been elucidated by means of IR, 1H NMR, 13CNMR,2D (HMBC, HSQC) and C.H.N Analysis. (paper)