Comparative radioprotective studies of chlorpromazine and cysteamine on rat bone development

The effect of two radioprotectors: chlorpromazine (CPZ) and cyteamine (Cys) were carried out, after intraperitonial injection, on serum Ca, inorganic phosphste. and alkaline phosphatase. The serum inorganic phosphate increased 6 hrs postirradiation, then decreased later on, while that of the femur bone increased. The serum calcium content increased 3 days post-irradiation then decreased, while that of the femur bone decreased throughout the period. The serum alkaline phosphatase activity increased 6 hrs post irradiation, while that of the femur bone decreased 24 hrs from γ-irradiation and continued during the rest of the experiment. The injection of CPZ or CYs pre-irradiation has partially recovered these changes. The double injection with CPZ and Cus has more radioprotective effect.3 tab