Published 2013
| Version v1
Book
Soluble factors-induced radio-resistance of human lung carcinoma cells: dual role of ATF-2 as transcription factor and DNA repair protein
Creators
- 1. Radiation Biology and Health Sciences Division, Bio-Medical Group, Bhabha Atomic Research Centre, Mumbai (India)
- 2. Department of Radiation Oncology, Tata Memorial Hospital, Mumbai (India)
Description
Cellular signalling associated with soluble factors secreted from tumor cells plays a critical role in pathogenesis and therapy of cancer. In present study, we have investigated mechanism of soluble factors induced survival and radioresistance in bystander human lung adenocarcinoma (A549) cells. Our results showed that IL-8 and VEGF, as major soluble factors in conditioned medium (CM), facilitate survival and proliferation of bystander A549 cells through activation of JNK- and p38-MAPK pathways. Hence, role of intracellular Ca+2 and cyclic AMP (cAMP), the two upstream secondary messengers of these pathways were studied
Additional details
Publishing Information
- Publisher
- Bhabha Atomic Research Centre
- Imprint Place
- Mumbai (India)
- Imprint Title
- Proceedings of the ninth DAE-BRNS life science symposium on current advances in immunobiology and cancer: abstracts
- Imprint Pagination
- 94 p.
- Journal Page Range
- p. 63
Conference
- Title
- 9. DAE-BRNS life science symposium on current advances in immunobiology and cancer
- Acronym
- LSS-2013
- Dates
- 28-30 Nov 2013
- Place
- Mumbai (India)
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 46034639
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- CARCINOMAS; DNA DAMAGES; GAMMA RADIATION; LUNGS; RADIOSENSITIVITY; RADIOTHERAPY
- Descriptors DEC
- BODY; DISEASES; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATIONS; RADIOLOGY; RESPIRATORY SYSTEM; SENSITIVITY; THERAPY