Fluorescent analysis of lymphocytes at pulmonary tuberculosis patients exposed to irradiation

On the territory of Belarus, damaging from the Chernobyl NPP accident, was scheduled negative pathological changes of a tuberculosis, which are displayed in heavier current of disease, decrease of an immunological reactivity and increase of a morbidity and mortality. For understanding and the interpretations of those changes were investigated lymphocytes of a peripheral blood of the pulmonary tuberculosis patients. 45 patients with the first time revealed widespread forms of a pulmonary tuberculosis, living on contaminated territories, with individual absorbed dozes of an external and internal irradiation 2 - 8 rem (at 9 patients - more than 8 rem), were investigated. Also 27 pulmonary tuberculosis patients and 25 healthy persons, which were not irradiated, were investigated too. The biophysical methods of research were used - proper and probe fluorescence, photosensitive death of cells. At the tuberculosis disease revealed changes in cells, indicating about increase of a metabolic processes level, decrease of an antioxidant system activity, a lipid bilayer viscosity and negative charge of cell membranes. The patients from contaminated territories had more expressed character of such changes. 8 refs., 1 tab