Clinical significance of changes of serum expression of IGF-I in patients with astrocytoma
Creators
- 1. Department of Neurosurgery, Laizhou People's Hospital, Shandong, Laizhou (China)
Description
Objective: To investigate the serum expression of IGF-I in patients with astrocytoma of different degrees of malignancy as well as the changes of levels after operative removal of the tumor. Methods: Serum IGF-I contents were measured with IRMA in 16 patients with Grade I-II astrocytoma and 14 patients with Grade III-IV astrocytoma both before and after operation as well as in 30 controls. Results: The serum contents of IGF-I in both groups of patients were significantly higher than those in controls (P<0.05). The levels in Grade III-IV patients were significantly higher than those in Grade I-II patients (P < 0.05 ). After operation, the levels dropped significantly (vs before operation, P<0.05). Conclusion: The serum contents of IGF - I in patients with astrocytoma were positively correlated with the degree of malignancy. Post-operative decrease of IGF-I contents was related to the decrease of tumor burden. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 18
- Journal Issue
- 6
- Journal Page Range
- p. 447-449
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 39093863
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ASTROCYTOMAS; BLOOD SERUM; GROWTH FACTORS; INSULIN; RADIOIMMUNOASSAY; SURGERY
- Descriptors DEC
- BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; DISEASES; GLIOMAS; HORMONES; IMMUNOASSAY; ISOTOPE APPLICATIONS; MATERIALS; MEDICINE; MITOGENS; NEOPLASMS; NERVOUS SYSTEM DISEASES; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; TRACER TECHNIQUES
Optional Information
- Notes
- 1 tab., 11 refs.