Published January 1985
| Version v1
Journal article
Radiation-induced crosslinks between thymine and phenylalanine
Description
OH radicals generated by ionizing radiation in aqueous solutions of thymine (T) and phenylalanine (Phe) induced crosslinking between thymine and phenylalanine. The crosslinked products were isolated and characterized by capillary gas chromatography-mass spectrometry. They are formed via OH radical adducts to thymine and phenylalanine and the reaction between dissimilar radicals is greatly favoured (T-Phe:Phe-Phe:T-T=0.46:0.14:0.05). The reaction mechanism presented may serve as a model for radiation or any free radical-induced crosslinks between DNA and proteins. (author)
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Volume
- 47
- Journal Issue
- 1
- Series
- Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med.
- Journal Page Range
- 63-69
- ISSN
- 0020-7616
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 16049856
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- AQUEOUS SOLUTIONS; BIOLOGICAL RADIATION EFFECTS; CROSS-LINKING; GAS CHROMATOGRAPHY; HYDROXYL RADICALS; MASS SPECTROSCOPY; PHENYLALANINE; THYMINE
- Descriptors DEC
- AMINO ACIDS; AROMATICS; AZINES; BIOLOGICAL EFFECTS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; CHROMATOGRAPHY; DISPERSIONS; HETEROCYCLIC COMPOUNDS; HOMOGENEOUS MIXTURES; HYDROXY COMPOUNDS; MIXTURES; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; POLYMERIZATION; PYRIMIDINES; RADIATION EFFECTS; RADICALS; SEPARATION PROCESSES; SOLUTIONS; SPECTROSCOPY; URACILS