Development of radioisotope production on the accelerator installation Tesla

This paper describes several aspects of the development of radioisotope production on the VINCY Cyclotron of the Accelerator Installation Tesla, in the Vinca Institute of Nuclear Sciences, Belgrade, Yugoslavia. The concept of radioisotope and radiopharmaceutical production is shown as well as the cross section of the part of the building where the channel for the radioisotope production H4 will be situated. The chemical processing of irradiated targets will be performed in the part of the Laboratory of Radioisotopes which is near (about 200 m) the cyclotron. Total area of the ''hot'' Laboratory is 144 m2 with all necessary connections (ventilation, power, pneumo post, etc). Based both on the cyclotron characteristics and on nuclear medicine needs in Yugoslavia we plan to produce 201Tl, 111In, 67Ga, 123I and 18F. The radioisotope production will start with 201Tl and the radiopharmaceutical 201TlCl, which is currently imported. The first ''cold'' experiments simulating the separation of 201Tl from irradiated target consisting of enriched 203TI were performed using the extraction method with butyl acetate. our experiments with 123I confirmed that all labelling procedures applied for 131I-radiopharmaceuticals currently produced in the Laboratory of Radioisotopes: ortho-iodo-hippuric acid-131I(131I-IHA) and meta-iodo-benzyl-guanidine-131I(131I-MIBG) could be applied for 123I-labelled radiopharmaceuticals. (author)