Clinical significance of determination of serum IGF-I, PRL and SE-cad levels in patients with prostatic carcinoma
Creators
- 1. Department of Urology, Changshu Municipal Second Hospital, Fifth Affiliated Clinical Medical College of Yangzhou Univ., Yangzhou (China)
Description
Objective: To study the clinical significance of determination of changes of serum IGF-I, PRL and SE-cad levels in patients with prostatic cancer. Methods: Serum IGF-I (with RIA), fPSA, PRL (with CLIA) and SE-cad (with ELISA) levels were determined in 34 patients with prostatic cancer, 34 patients with BPH, and 35 controls. Results: Serum IGF-I, fPSA, PRL and SE-cad levels in the patients with BPH were significantly higher than those in the controls (P< 0.05), the levels in patients with prostatic cancer were even higher. With respect to the diagnostic sensitivity both the sensitivity of combined determination of fPSA + IGF-I and fPSA + SE - cad were significantly higher than that of single fPSA determination. Combined determination of fPSA + PRL yielded a not significantly lower sensitivity than that with single fPSA (P>0.05). For specificity, fPSA + SE-cad was significantly more specific (P>0.05), fPSA+IGF-I was more specific but not significantly, but fPSA + PRL was significantly less specific. Conclusion: Combined determination of serum fPSA with IGF-I, SE-cad could improve the diagnostic accuracy and specificity in patients with prostatic cancer. (authors)
Additional details
Publishing Information
- Journal Title
- Journal of Radioimmunology
- Journal Volume
- 21
- Journal Issue
- 6
- Journal Page Range
- p. 500-502
- ISSN
- 1008-9810
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 41049866
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ACCURACY; ANTIGENS; BLOOD SERUM; CARCINOMAS; CHEMILUMINESCENCE; COMPARATIVE EVALUATIONS; DIAGNOSIS; ENZYME IMMUNOASSAY; GROWTH FACTORS; INSULIN; LTH; MUCOPOLYSACCHARIDES; PROSTATE; RADIOIMMUNOASSAY; SENSITIVITY; SPECIFICITY; UROGENITAL SYSTEM DISEASES
- Descriptors DEC
- AMINES; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD PLASMA; BODY; BODY FLUIDS; CARBOHYDRATES; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION; EVALUATION; GLANDS; GONADOTROPINS; HORMONES; IMMUNOASSAY; ISOTOPE APPLICATIONS; LUMINESCENCE; MALE GENITALS; MATERIALS; MITOGENS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PHOTON EMISSION; PITUITARY HORMONES; POLYSACCHARIDES; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; SACCHARIDES; TRACER TECHNIQUES
Optional Information
- Notes
- 2 tabs., 11 refs.