Contrasting feature in the repopulation of host-type T cells in the spleens of F1----P and P----F1 radiation bone marrow chimeras
- 1. Tokyo Metropolitan Institute of Gerontology, Japan
Description
The regeneration and persistence of host- and donor-derived T cells were examined in the thymus as well as the spleen of mouse radiation bone marrow chimeras of two semiallogeneic combinations (F1----P, P----F1) with different Thy-1 markers on T cells of donor and host origins. An unexpectedly large number of host-type T cells were recovered from the spleens of F1----P chimeras, amounting to as high as 45 and 25% of total T cells at 6 and 14 weeks after bone marrow transplantation (BMT), respectively. To the contrary, the residual host-type T cells in the spleens of P----F1 chimeras disappeared quickly, resulting in less than 0.1% of total T cells at 6 weeks after BMT. It was also revealed that the number of host-type T cells in the spleens of F1----P chimeras decreased in proportion to increase of radiation dose given to the recipients
Additional details
Publishing Information
- Journal Title
- Cell. Immunol.
- Journal Issue
- no.1
- Series
- Cell. Immunol.
- ISSN
- 0008-8749
- CODEN
- CLIMB
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18064712
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL REGENERATION; BONE MARROW; LYMPHOCYTES; MICE; RADIATION CHIMERAS; SPLEEN; SURVIVAL TIME; THYMUS; TRANSPLANTS
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CHIMERAS; CONNECTIVE TISSUE CELLS; HEMATOPOIETIC SYSTEM; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; MATERIALS; MOSAICISM; ORGANS; RODENTS; SOMATIC CELLS; TISSUES; VERTEBRATES