Published August 1981 | Version v1
Journal article Metadata-only

Thyorid function after mantle field radiation therapy

Creators

  • 1. Mainz Univ. (Germany, F.R.). Inst. fuer Klinische Strahlenkunde

Description

48 patients with malignant lymphoma received a 60Co-radiation dose of 30 to 50 Gy using the mantle field technique. Thyroid function tests were performed 34 to 92 months after radiation therapy. One patient developed myxedema, ten (20.8%) had subclinical hypothyroidism and six (12.5%) latent hypothyroidism. The incidence of hypothyroidism after treatment of malignant lymphomas is summarized in a review of the literature. Discrepancies on the incidence of hypothyroidism were found, and their possible cause is discussed. Periodic examinations of all patients with thyroid radiation exposure are recommended. The examination can be limited to measurement of TSH concentration and palpation of the thyroid for nodules. (orig.)

Abstract (German)

48 Patienten erhielten wegen eines malignen Lymphoms eine 60Co-Radiotherapie in Form eines thorakalen Grossfeldes. Die eingestrahlte Dosis betrug 30 bis 50 Gy. Die 34 bis 92 Monate spaeter durchgefuehrten Schilddruesenfunktionsuntersuchungen zeigten in einem Fall ein Myxoedem, bei 10 Patienten (20,8%) eine subklinische Hypothyreose und bei 6 Patienten (12,5%) eine latente Hypothyreose. Die Hypothyreoseinzidenz nach Strahlentherapie maligner Lymphome wird in einem Literaturueberblick zusammengestellt. Die moegliche Ursache fuer die unterschiedlichen Haeufigkeitsangaben wird diskutiert. Es werden bei allen Patienten, deren Schilddruese im Bestrahlungsfeld liegt, routinemaessige Nachuntersuchungen empfohlen, die sich auf die basale TSH-Bestimmung sowie zum Tumorausschluss auf den Schilddruesentastbefund beschraenken koennen. (orig.)

Additional details

Additional titles

Original title (German)
Schilddruesenfunktion nach thorakaler Mantelfeldbestrahlung

Publishing Information

Journal Title
Strahlentherapie
Journal Volume
157
Journal Issue
8
Series
Strahlentherapie.
Journal Page Range
499-507
ISSN
0039-2073

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
13665186
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CHEST; DELAYED RADIATION EFFECTS; FRACTIONATED IRRADIATION; GAMMA RADIATION; GAMMA SOURCES; HYPOTHYROIDISM; ISOMERIC NUCLEI; LATENCY PERIOD; LYMPHOMAS; PATIENTS; PERTECHNETATES; RADIOTHERAPY; SCINTISCANNING; STATISTICS; TECHNETIUM 99; THYROGLOBULIN; THYROID; THYROID HORMONES; TRH; TSH
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; BODY AREAS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTROMAGNETIC RADIATION; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; GLOBULINS; HORMONES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATHEMATICS; MEDICINE; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; OXYGEN COMPOUNDS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; RADIATION EFFECTS; RADIATION SOURCES; RADIATIONS; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM COMPOUNDS; TECHNETIUM ISOTOPES; THERAPY; TRANSITION ELEMENT COMPOUNDS; YEARS LIVING RADIOISOTOPES