The protective role of therapeutic hypothermia in the 10 Gy irradiated Balb/C mice
Creators
- 1. China Institute for Radiation Protection, Taiyuan (China)
Description
Objective: To investigate the protective role of therapeutic hypothermia in the acute and high-dose irradiated mice. Methods: Two groups of Balb/C mice each 15 were received whole body irradiation with 60Co source. One group of Mice were administered therapeutic hypothermia following irradiation. The indices of survival time, survival rate, protection index, and peripheral blood counts as well as paraffin-embedded tissue sections were observed. Results: Survival time extended averagely 3.4 days and protection index attained 1.216 in the hypothermia-treated group compared with the group treated only with radiation. And both the reduction of lymphocytes and injuries of organs induced by irradiation were retarded in the hypothermia-treated group too, the number of lymphocytes at 6 hours and 24 hours after irradiation was higher than that of the group treated only with radiation. Conclusion: Therapeutic hypothermia administered immediately following irradiation might play a protective role in mice exposure to high-dose irradiation. (authors)
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Health
- Journal Volume
- 26
- Journal Issue
- 6
- Journal Page Range
- p. 642-646
- ISSN
- 1004-714X
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 50069901
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY;
- Descriptors DEI
- ANIMAL TISSUES; BLOOD COUNT; COBALT 60; COMPARATIVE EVALUATIONS; HYPOTHERMIA; IRRADIATION; LYMPHOCYTES; MICE; ORGANS; RADIATION DOSES; RADIATION INJURIES; SAFETY; SURVIVAL TIME; WHOLE-BODY COUNTING
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; BODY TEMPERATURE; COBALT ISOTOPES; CONNECTIVE TISSUE CELLS; COUNTING TECHNIQUES; DISEASES; DOSES; EVALUATION; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LEUKOCYTES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; RODENTS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- 4 figs., 2 tabs., 7 refs.