Published February 1984 | Version v1
Journal article Metadata-only

First results of visualizing neuroblastoma with 131I-meta-iodobenzylguanidine

Creators

  • 1. Tuebingen Univ. (Germany, F.R.). Abt. fuer Nuklearmedizin
  • 2. Tuebingen Univ. (Germany, F.R.). Kinderklinik

Description

5 children suffering from neurobalstoma were investigated with 131I-MIBG. 4 subjects with still existing tumorous tissue showed intensive specific tumor uptake, one subject without evidence of tumorous tissue and normal catecholamine level did not show focal activity. 131I-MIBG deserved further evaluation for diagnosis of neuroblastoma as well as for therapy because of the intensive and specific tumour uptake. As cases of neuroblastoma without MIBG uptake were reported by Shapiro and Fischer a compilation of these cases is highly desired. (orig.)

Abstract (German)

Bei 5 Neuroblastom-Kindern, untersucht mit 131J-MIBG, zeigten alle 4 Kinder mit noch vorhandenem Tumor eine hohe spezifische Anreicherung der Substanz im Neuroblastom. Ein, z. Zt. tumorfreies, Kind mit normalem Katecholaminspiegel blieb ohne Herdbefund. 131J-MIBG sollte deshalb weiterhin als Diagnostikum fuer das Neuroblastom erprobt werden. Die therapeutische Anwendung dieser Substanz sollte bei der hohen spezifischen Anreicherung im Tumor geprueft werden. Da in der Literatur bisher auch fehlende Anreicherungen bei Neuroblastom beobachtet wurden (Shapiro, Fischer), erscheint eine Zusammenstellung der Ergebnisse moeglichst vieler, mit 131J-MIBG untersuchter Neuroblastom-Kinder wuenschenswert. (orig.)

Additional details

Additional titles

Original title (German)
Erste Untersuchungen zur szintigraphischen Darstellung von Neuroblastomen mit

Publishing Information

Journal Title
Nuc Compact
Journal Volume
15
Journal Issue
1
Series
CODEN: CNNMA.;Nuc Compact.
Journal Page Range
23-26
ISSN
0344-3752

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
15056319
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CAT SCANNING; CATECHOLAMINES; CHILDREN; DIAGNOSIS; GUANIDINES; IMAGES; IODINE 131; NEOPLASMS; NERVE CELLS; OPACITY; PATHOLOGICAL CHANGES; PATIENTS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SCINTISCANNING
Descriptors DEC
AMINES; ANIMAL CELLS; ANIMALS; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBONIC ACID DERIVATIVES; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MAN; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; OPTICAL PROPERTIES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PHENOLS; PHYSICAL PROPERTIES; POLYPHENOLS; PRIMATES; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SOMATIC CELLS; TOMOGRAPHY; VERTEBRATES