Published May 2019 | Version v1
Journal article Metadata-only

High phthalate exposure increased urinary concentrations of quinolinic acid, implicated in the pathogenesis of neurological disorders: Is this a potential missing link?

Creators

  • 1. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA (United States)
  • 2. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA (United States)
  • 3. Ethos Research & Development, Newport, KY (United States)
  • 4. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA (United States)
  • 5. Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA (United States)
  • 6. Department of Epidemiology Harvard T. H. Chan School of Public Health, Boston, MA (United States)

Description

Quinolinic acid (QA), a neuroactive metabolite of the Kynurenine Pathway (KP), is an excitotoxin that is implicated in the pathogenesis of many neurological disorders. KP is the main tryptophan degradation pathway. Phthalates can structurally mimic tryptophan metabolites and diets containing phthalates in rats enhanced the production and excretion of QA. However, there are no human studies that have examined the association between phthalates and QA.

Additional details

Identifiers

DOI
10.1016/j.envres.2019.02.034;
PII
S0013935119301148;

Publishing Information

Journal Title
Environmental Research
Journal Volume
172
Journal Page Range
p. 430-436
ISSN
0013-9351
CODEN
ENVRAL

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55023752
Subject category
S54: ENVIRONMENTAL SCIENCES;
Descriptors DEI
ECOLOGICAL CONCENTRATION; KYNURENINE; METABOLITES; PATHOGENESIS; PHTHALATES; RATS; TRYPTOPHAN
Descriptors DEC
AMINO ACIDS; ANIMALS; AROMATICS; AZAARENES; AZOLES; CARBOXYLIC ACID SALTS; CARBOXYLIC ACIDS; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; INDOLES; KETO ACIDS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RODENTS; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2019 Elsevier Inc. All rights reserved.