Radiopharmacokinetics: utilization of nuclear medicine techniques in the non-invasive study of drug distribution. Progress report

These studies provide a basic framework in which the radiopharmokinetic models described in this report may be tested experimentally. Volume calibration factors, corrections for overlying and underlying activity, and estimates of the amount of noise in quantitative projection and tomographic images have been developed, with emphasis on particular compartments within a rat-size phantom. Studies have also been performed with live rats and the results interpreted with the aid of the physical studies described above. We expect that similar types of analyses and calibrations will be necessary in the upcoming clinical studies. 32 refs., 24 figs., 12 tabs