Published February 1986 | Version v1
Journal article Metadata-only

Ruthenocene-amphetamine analogues as radiodiagnostics: Brain affinity of 103Ru-labelled ruthenocenyl-isopropylamine

Creators

  • 1. Freie Univ. Berlin (Germany, F.R.). Inst. fuer Pharmazie

Description

N-alkyl derivatives of 1-ruthenocenyl-2-amino-propan (Rc-amphetamine) were labelled with 103Ru and their organ distributions were measured in mice and rats. All Rc-amphetamines showed a high affinity for brain and lung. A concentration ratio brain/blood up to 17:1 and lung/blood up to 80:1 was measured. The advantages of 97Ru labelled Rc-amphetamine compared to 123J labelled amphetamine for measurement of regional cerebral blood flow are discussed. (orig.)

Abstract (German)

Verschiedene N-alkyl-Derivate des 1-Ruthenocenyl-2-amino-propan (Rc-Amphetamin), einem Analogon des Amphetamins, wurden mit radioaktivem Ruthenium markiert und die Organverteilung bei Maeusen und Ratten gemessen. Nach i.v. Injektion zeigten alle Rc-Amphetaminderivate einen schnellen Einstrom in das Gehirn und die Lunge. Der Quotient der Radioaktivitaetskonzentration Gehirn/Blut lag maximal bei 17:1 und Lunge/Blut bei 80:1. Auf die Vorteile von 97Ru-markiertem Rc-Amphetamin im Vergleich zu 123J-markierten Amphetaminderivaten bei der Bestimmung der Gehirndurchblutung wird hingewiesen. (orig.)

Additional details

Additional titles

Original title (German)
Amphetaminanaloga des Ruthenocens als Radiodiagnostika: Gehirn-Affinitaet von Ruthenocenyl-isopropylamin

Publishing Information

Journal Title
RoeFo - Fortschr. Geb. Roentgenstr. Nuklearmed.
Journal Volume
144
Journal Issue
2
Series
RoeFo - Fortschr. Geb. Roentgenstr. Nuklearmed.
Journal Page Range
227-229
ISSN
0340-1618
CODEN
RFGND

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
18050846
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
AMPHETAMINES; BLOOD FLOW; BRAIN; DIAGNOSIS; IODINE 123; LABELLED POOL TECHNIQUES; LUNGS; MICE; RADIOPHARMACEUTICALS; RATS; RUTHENIUM COMPOUNDS; RUTHENIUM 97; TISSUE DISTRIBUTION; UPTAKE
Descriptors DEC
AMINES; ANALEPTICS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM AGENTS; DAYS LIVING RADIOISOTOPES; DISTRIBUTION; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; RUTHENIUM ISOTOPES; SYMPATHOMIMETICS; TRACER TECHNIQUES; TRANSITION ELEMENT COMPOUNDS; VERTEBRATES