Preliminary applied study of assessment ischemic/viable myocardium by 99Tcm-HL91

Objective: To investigate the representation of 99Tcm-HL91 in the ischemic myocardium, evaluate the diagnosis value of 99Tcm-HL91 on hypoxic but viable myocardium. Methods: Six patients with cardiac infarction all underwent 99Tcm-MIBI SPECT and 99Tcm-HL91 SPECT. Average radioactivity of ischemic area and normal area were respectively obtained by ROI (2 x 2 pixels) on heart minor axis of images, And the radioactivity ratios of target (ischemic area)-to-non target(normal area)were calculated. Results: In image of 99Tcm-HL91 SPECT, two patients who's radioactivity coloboma of 99Tcm-MIBI image could be filled with 99Tcm-HL91, four patients were not caught sight of obvious filling up. Conclusion 99Tcm-HL91 can be selectively uptaken by ischemic and hypoxic but viable myocardium. it combination of 99Tcm-MIBI SPECT may be good for accurate diagnosis and differentiation of viable myocardium. (authors)