Published 1987 | Version v1
Journal article Metadata-only

Local anaesthetics modifying the dermal response of irradiation

Creators

  • 1. Astra Alab AB, Soedertaelje (Sweden)
  • 2. University Hospital, Uppsala (Sweden). Dept. of Oncology
  • 3. University Hospital, Uppsala (Sweden). Dept. of Clinical Pathology
  • 4. University Hospital, Uppsala (Sweden). Dept. of Plastic Surgery

Description

In a series of experiments in rabbits the dermal reaction, provoked by a single dose or intermittent doses of irradiation, was prevented or modified by topical or parenteral administration of local anaesthetics, compared to irradiated control animals. The topical application of a eutectic lidocaine/prilocaine cream, EMLA 5%, was found to be more effective than intravenously injected lidocaine (Xylocain 1%). (orig.)

Additional details

Additional titles

Subtitle (English)
An experimental study

Publishing Information

Journal Title
Acta Oncol. (Stockh.)
Journal Volume
26
Journal Issue
6
Series
Acta Oncol. (Stockh.).
Journal Page Range
467-476
CODEN
ACTOE

INIS

Country of Publication
Sweden
Country of Input or Organization
Sweden
INIS RN
19067179
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANESTHETICS; BIOLOGICAL RADIATION EFFECTS; ELECTRON BEAMS; HISTOLOGY; LINEAR ACCELERATORS; LOCAL IRRADIATION; RABBITS; RESPONSE MODIFYING FACTORS; SKIN
Descriptors DEC
ACCELERATORS; ANIMALS; BEAMS; BIOLOGICAL EFFECTS; BODY; CENTRAL NERVOUS SYSTEM AGENTS; CENTRAL NERVOUS SYSTEM DEPRESS; DRUGS; IRRADIATION; LEPTON BEAMS; MAMMALS; ORGANS; PARTICLE BEAMS; RADIATION EFFECTS; VERTEBRATES