Protective and promoting effects of fetal muscle conditioned medium on hematopoiesis in irradiated mice
Creators
- 1. Lanzhou Medical College (China). Inst. of Hematology
Description
The Balb/C mice were whole body irradiated with γ-rays (60Co, 6.5 Gy), and given human fetal muscle conditioned medium (FMCM) before and after irradiation, the protective and promoting effects on hematopoiesis in irradiated mice were observed. The results showed that FMCM given I. P(2.5∼5.0 ml kg-1 d-1 x 5 d) before 6.5 Gy whole body γ-irradiation was able to protect the colony forming unite-spleen (CFU-S), and reduce the decreases of red blood cells (RBC), white blood cells (WBC) and heme globin (Hb) in peripheral blood; FMCM given after irradiation could effectively promote the hemopoietic reconstruction in spleen and the increases of RBC, WBC and Hb in peripheral blood. The above results suggest that FMCM has good protective and promoting effects on reducing hematopoietic damage caused by irradiation
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Research and Radiation Processing
- Journal Volume
- 14
- Journal Issue
- 1
- Journal Page Range
- p. 55-58.
- ISSN
- 1000-3436
- CODEN
- FYYXEA
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 27050695
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACUTE IRRADIATION; BIOLOGICAL RECOVERY; BLOOD FORMATION; BLOOD PLASMA; COBALT 60; CULTURE MEDIA; FETUSES; HEMATOPOIETIC SYSTEM; MICE; MUSCLES; RADIATION INJURIES; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; STEM CELLS
- Descriptors DEC
- ACUTE EXPOSURE; ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BODY; BODY FLUIDS; COBALT ISOTOPES; DISEASES; DRUGS; INJURIES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIATION EFFECTS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RODENTS; SOMATIC CELLS; VERTEBRATES; YEARS LIVING RADIOISOTOPES