Published March 2010 | Version v1
Journal article Metadata-only

Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT

Creators

  • 1. Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sec. 2, Li-Nong St., Bei-tou, 112 Taipei, Taiwan (China)
  • 2. Institute of Nuclear Engineering and Science, National Tsing-Hua University, Hsinchu, Taiwan (China)
  • 3. Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan (China)
  • 4. Department of Radiation Oncology and Hospice Center, Mackay Memorial Hospital, Taipei, Taiwan (China)
  • 5. Department of Nuclear Medicine, Veterans General Hospital, Taipei, Taiwan (China)

Description

A new phenylboric acid derivative entrapped lipiodol (PBAD-lipiodol) was developed as a boron carrier for the boron neutron capture therapy (BNCT) of hepatoma in Taiwan. The biodistribution of both PBAD-lipiodol and BPA-fructose was assayed in GP7TB hepatoma-bearing rat model. The highest uptake of PBAD-lipiodol was found at 2 h post injection. The application of BNCT for the hepatoma treatment in tumor-bearing rats is suggested to be 2-4 h post PBAD-lipiodol injection.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2009.12.033

Additional details

Identifiers

DOI
10.1016/j.apradiso.2009.12.033;
PII
S0969-8043(09)00817-3;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
68
Journal Issue
3
Journal Page Range
p. 422-426
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
41065204
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
BORON; CARRIERS; FLUORINE 18; FRUCTOSE; HEPATOMAS; LIPIODOL; LIVER; NEUTRON CAPTURE THERAPY; PHENYLALANINE; RADIOPHARMACEUTICALS
Descriptors DEC
AMINO ACIDS; AROMATICS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CARBOXYLIC ACIDS; CARCINOMAS; CONTRAST MEDIA; DIGESTIVE SYSTEM; DISEASES; DRUGS; ELEMENTS; FLUORINE ISOTOPES; GLANDS; HEXOSES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KETONES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MEDICINE; MONOSACCHARIDES; NANOSECONDS LIVING RADIOISOTOPES; NEOPLASMS; NEUTRON THERAPY; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; OILS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; OTHER ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; SACCHARIDES; SEMIMETALS; THERAPY

Optional Information

Copyright
Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.