Published 2011 | Version v1
Journal article Metadata-only

Synthesis and preliminary evaluation of antinociceptive activity of novel isoxazolyl-aryl-hydrazones

Creators

  • 1. Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Ciencias Farmaceuticas
  • 2. Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Antibioticos

Description

New 2-isoxazoline aldehydes were synthesized, in good yields, from cycloadduct of the 1,3-dipolar cycloaddition reaction between endocyclic enecarbamate and carboethoxyformonitrile oxide (CEFNO). Condensation of these 2-isoxazoline aldehydes with several phenyl-hydrazines produced new isoxazolyl-aryl-hydrazones, which showed low toxicity and excellent antinociceptive activity, when compared to dipyrone. The antinociceptive activity of isoxazolyl-aryl-hydrazones was performed using the acetic acid-induced mice abdominal constrictions test. (author)

Availability note (English)

Available from http://www.scielo.br/pdf/qn/v34n1/v34n1a15.pdf

Additional details

Additional titles

Original title (Portuguese)
Sintese e avaliacao preliminar de atividade antinociceptiva de novas isoxazolil-aril-hidrazonas

Identifiers

URL
http://www.scielo.br/pdf/qn/v34n1/v34n1a15.pdf;

Publishing Information

Journal Title
Quimica Nova On-Line
Journal Volume
34
Journal Issue
1
Journal Page Range
p. 76-81
ISSN
1678-7064

INIS

Country of Publication
Brazil
Country of Input or Organization
Brazil
INIS RN
42034196
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
CARBON 13; DMSO; HYDRAZINE; HYDROGEN 1; LIQUID COLUMN CHROMATOGRAPHY; MASS SPECTRA; METHANOL; NMR SPECTRA; PYRONES; PYRROLIDINES; SILICA GEL; ULTRAVIOLET SPECTRA
Descriptors DEC
ADSORBENTS; ALCOHOLS; AMINES; AZOLES; CARBON ISOTOPES; CHROMATOGRAPHY; EVEN-ODD NUCLEI; HETEROCYCLIC COMPOUNDS; HETEROCYCLIC OXYGEN COMPOUNDS; HYDROGEN ISOTOPES; HYDROXY COMPOUNDS; ISOTOPES; LIGHT NUCLEI; NITROGEN COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; PYRANS; PYRROLES; SEPARATION PROCESSES; SPECTRA; STABLE ISOTOPES; SULFOXIDES