3H-1H shift correlation NMR spectroscopy

Three two-dimensional 3H-1H chemical shift correlation experiments are described, all using familiar pulse sequences. The experiments reveal the chemical shifts of the 1H spins which are coupled scalarly to a 3H spin and, thus, assist in the unambiguous location of this 3H spin within the molecule. The limitations for molecules involving a 3H spin which is coupled differently to various 1H spins are indicated. In practice, the detection limit is of the order of 100 MBq per 3H-labelling site. (author)