Published January 1978 | Version v1
Journal article Metadata-only

DNA synthesis and DNA repair in chronic rheumatism when exposed to low doses of natural radioactivity (radon)

Creators

  • 1. Innsbruck Univ. (Austria). Abt. fuer Physikalische Medizin und Rheumatologie
  • 2. Oesterreichische Studiengesellschaft fuer Atomenergie G.m.b.H., Seibersdorf. Inst. fuer Biologie

Description

Elevated natural radioactivity during a treatment at Badgastein (Austria) caused an increase in DNA-repair of lymphocytes of patients with ankylosing spondylitis and osteoarthritis. Semiconservative DNA-synthesis was remarkably lower after the treatment in patients with ankylosing spondylitis and a small decrease was obtained also in lymphocytes of osteoarthritis patients. These effects are discussed in relation to late effects. (orig.)

Abstract (German)

Patienten mit Spondylitis ankylosans und Arthrose zeigten nach einer Kur in Badgastein (Oesterreich) unter Einwirkung natuerlich erhoehter Radioaktivitaet einen Anstieg in der DNA-Reparatur-Kapazitaet von Lymphozyten. Die semikonservative DNA-Synthese war bei Patienten mit Spondylitis ankylosans bei Kurende deutlich gesenkt. Auch bei Patienten mit Arthrose war eine schwache Abnahme dieser Synthese in den Lymphozyten nachweisbar. Diese Erscheinungen werden in bezug auf Spaetwirkungen diskutiert. (orig.)

Additional details

Additional titles

Original title (German)
DNA-Synthese und DNA-Repair bei chronischem Rheumatismus unter Einwirkung kleiner Dosen natuerlicher Radioaktivitaet (Radon)

Publishing Information

Journal Title
Z. Rheumatol.
Journal Volume
37
Journal Issue
1/2
Series
Z. Rheumatol.
Journal Page Range
17-22

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
9417637
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BALNEOLOGY; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; BIOSYNTHESIS; DNA; LYMPHOCYTES; METABOLISM; NATURAL RADIOACTIVITY; PATIENTS; RADON; RHEUMATIC DISEASES; SPONDYLITIS; THYMIDINE; TRACER TECHNIQUES; TRITIUM COMPOUNDS
Descriptors DEC
ANIMAL CELLS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELEMENTS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; ISOTOPE APPLICATIONS; LEUKOCYTES; MEDICINE; NONMETALS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIOACTIVITY; RARE GASES; RIBOSIDES; SKELETAL DISEASES; SOMATIC CELLS; SYNTHESIS