Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain. A positron emission tomography study
Creators
- 1. Kyushu Univ., Fukuoka (Japan). Graduate School of Medical Sciences
Description
We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N-methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p<0.01-p<0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R. (author)
Additional details
Publishing Information
- Journal Title
- Annals of Nuclear Medicine
- Journal Volume
- 14
- Journal Issue
- 2
- Journal Page Range
- p. 97-101
- ISSN
- 0914-7187
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 31032621
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BENZILIC ACID; CARBON 11; CEREBELLUM; CEREBRUM; HIPPOCAMPUS; POSITRON COMPUTED TOMOGRAPHY; RECEPTORS; SEX DEPENDENCE; UPTAKE
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; BRAIN; CARBON ISOTOPES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HYDROXY ACIDS; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOISOTOPES; TOMOGRAPHY