Published August 1985 | Version v1
Journal article Metadata-only

Synthesis and biodistribution of [18F]-5-fluorocytosine

Creators

  • 1. Vrije Univ., Amsterdam (Netherlands). Radionucliden Centrum

Description

The radiopharmaceutical [18F]-5-fluorocytosine was prepared by reaction of [18F]-acetylhypofluorite with cytosine in acetic acid and was isolated in an overall radiochemical yield of 20%. Tissue distribution studies in sarcoma-bearing rats indicated in vivo stability, limited tissue uptake and rapid urinary excretion. (author)

Additional details

Publishing Information

Journal Title
Nucl. Med. Commun.
Journal Volume
6
Journal Issue
8
Series
Nucl. Med. Commun.
Journal Page Range
455-459
ISSN
0143-3636

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
16084088
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
CHEMICAL PREPARATION; CYTOSINE; DISTRIBUTION; FLUORINE 18; NEOPLASMS; RADIOPHARMACEUTICALS; RATS
Descriptors DEC
AMINES; ANIMALS; AZINES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; DISEASES; DRUGS; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PYRIMIDINES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SYNTHESIS; VERTEBRATES