Published February 1998 | Version v1
Journal article Metadata-only

Radiosensitivity of thymocytes in different stages of their differentiation

Creators

  • 1. Norman Bethune Univ. of Medical Sciences, Changchun (China). MH Radiobiology Research Unit

Description

Kunming mice were whole-body irradiated with 0.5∼4.0 Gy X-rays. The effect on different subset of thymocytes were analyzed by flow cytometry with fluorescent monoclonal antibodies 24 hour after irradiation. This results showed that the radiosensitivity varied in different stages of differentiation of the thymocytes. The order of radiosensitivity was: CD4+CD8+>CD4-CD8->CD4-CD8+>CD4+CD8-, suggesting a relative radioresistance of the mature thymocytes. The D37 values of CD4+CD8+, CD4-CD8-, CD4-CD8+ and CD4+CD8- subsets were respectively 0.76, 0.92, 1.77 Gy and 3.67 Gy. The D37 value of the thymocytes as a whole population was 0.84 Gy. The D37 value of CD3+ cell was 2.0 Gy

Additional details

Publishing Information

Journal Title
Journal of Radiation Research and Radiation Processing
Journal Volume
16
Journal Issue
1
Journal Page Range
p. 38-41
ISSN
1000-3436

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
29044100
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CELL DIFFERENTIATION; MICE; RADIOSENSITIVITY; THYMOCYTES; THYMUS; WHOLE-BODY IRRADIATION; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BODY; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; IONIZING RADIATIONS; IRRADIATION; LYMPHATIC SYSTEM; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES