Published November 2007 | Version v1
Journal article Metadata-only

Correlation between joint [F-18] FDG PET uptake and synovial TNF-α concentration: A study with two rabbit models of acute inflammatory arthritis

Creators

  • 1. Department of Physical Medicine and Rehabilitation, Taipei Medical University-Wan Fang Hospital, 111 Hsing-Long Road Sec. 3, Taipei 11696, Taiwan (China)
  • 2. Department of Nuclear Medicine, Taipei Veterans General Hospital, 201 Shih-Pai Road Sec. 2, Taipei 11217, Taiwan (China)
  • 3. Department of General Education, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan (China)
  • 4. Graduate Institute of Medical Informatics, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11031, Taiwan (China)

Description

The objective of this study was to verify that the [F-18]FDG PET synovial uptake is correlated with the synovial fluid (SF) TNF-α concentration. Two rabbit models of acute inflammatory arthritis induced by human interleukin-8 and lipopolysaccharide were used. Modified standard uptake values (MSUVs) obtained from PET images of the animals were compared with results of SF TNF-α measurements. Statistically significant correlations were found between the MSUVs and the SF TNF-α ratios. An equation to estimate the TNF-α ratio from a MSUV was also derived

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2007.06.006

Additional details

Identifiers

DOI
10.1016/j.apradiso.2007.06.006;
PII
S0969-8043(07)00172-8;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
65
Journal Issue
11
Journal Page Range
p. 1221-1226
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
39044002
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
FLUORINE 18; HUMAN POPULATIONS; INFLAMMATION; JOINTS; POSITRON COMPUTED TOMOGRAPHY; RABBITS; RADIOPHARMACEUTICALS; RHEUMATIC DISEASES; UPTAKE
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MAMMALS; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; PATHOLOGICAL CHANGES; POPULATIONS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYMPTOMS; TOMOGRAPHY; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2007 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.