Published January 1984 | Version v1
Journal article Metadata-only

Effect of hypoxic sensitizers on survival of irradiated yeast haplents

Creators

  • 1. Akademiya Meditsinskikh Nauk SSSR, Obninsk. Nauchno-Issledovatel'skij Inst. Meditsinskoj Radiologii

Description

A study was made of the oxygen effect and the radiosensitizing acting of metronidazole and misonidazole on hypoxic cells of irradiated yeast haplonts. It was shown that metronidazole did not increase the radiosensitivity of all the strains under study while the senitizing effectiveness of oxygen and misonidazole approximated the values characteristic of different repair-deficient rad-mutants. Possible causes of the radiosensitizing effects observed are discussed

Additional details

Additional titles

Original title (Russian)
Действие гипоксических сенсибилизаторов на выживаемост' дрожжей-гаплонтов, облученных ионизирующей радиацией

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
24
Journal Issue
1
Series
Radiobiologiya.
Journal Page Range
52-55
ISSN
0033-8192

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
15055874
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
ANOXIA; DIPLOIDY; DOSE-RESPONSE RELATIONSHIPS; HAPLOIDY; LINEAR ACCELERATORS; METRONIDAZOLE; MISONIDAZOLE; MUTANTS; RADIOSENSITIVITY; RESPONSE MODIFYING FACTORS; SURVIVAL CURVES; YEASTS
Descriptors DEC
ACCELERATORS; ALCOHOLS; ANTINEOPLASTIC DRUGS; AZOLES; DRUGS; FUNGI; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; MICROORGANISMS; NITRO COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PLANTS; PLOIDY; RADIOSENSITIZERS

Optional Information

Notes
For English translation see the journal Radiobiology (Translation) (USA).