Effect of free radicals released from pulmonary alveolar phagocytes on development of radiation pneumonia in rats
Creators
- 1. Institute of Radiation Medicine, Beijing (China)
Description
Measuring the hydroxyproline (HyP) content in rat lungs and the chemiluminescence (CL) of bronchus alveolar lavage fluid cell (BALFC) at 0.5, 1 and 2 months after irradiation with 60Co γ-rays respectively, we found that the amount of BALFC and its CL stimulated by zymosan and the pulmonary HyP content were apparently increased after irradiation, and these alternations took a favourable turn when selenium was supplemented to irradiated rats, suggesting that selenium protected the rats from radiation injury of lung. In addition, we found that there were certain interrelations between the multiplication of pulmonary fibrocytes and the free radicals released from accumulated BALFC in pulmonary alveoli, indicating that the free radicals produced from alveolar phagocytes may be an important factor in development of rat radiation pneumonia
Additional details
Publishing Information
- Journal Title
- Chinese Journal of Radiological Medicine and Protection
- Journal Volume
- 16
- Journal Issue
- 2
- Journal Page Range
- p. 96-99.
- ISSN
- 0254-5098
- CODEN
- ZFYZDY
INIS
- Country of Publication
- China
- Country of Input or Organization
- China
- INIS RN
- 27061983
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; CELL PROLIFERATION; CHEST; FIBROBLASTS; GAMMA RADIATION; HYDROXYPROLINE; LOCAL IRRADIATION; LUNGS; PHAGOCYTES; PNEUMONIA; RADICALS; RATS
- Descriptors DEC
- AMINES; AMINO ACIDS; ANIMAL CELLS; ANIMALS; AZOLES; BIOLOGICAL EFFECTS; BODY; BODY AREAS; CARBOXYLIC ACIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HYDROXY ACIDS; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; PYRROLIDINES; RADIATION EFFECTS; RADIATIONS; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM DISEASES; RODENTS; SOMATIC CELLS; VERTEBRATES