Clinical value of ⁹⁹Tc^m-MIBI imaging combined with serum tumor markers in diagnosis of benign and malignant pulmonary nodules

Objective: To evaluate the significance of ⁹⁹Tc^m-MIBI imaging combined with serum tumor markers (NSE, CYFRA21-1) in diagnosis of pulmonary nodules. Methods: 54 patients who were detected pulmonary nodules by Computed Tomography(CT) were involved in this study. All of them underwent ⁹⁹Tc^m-MIBI imaging and serum tumor markers testing. The sensitivity, specificity and accuracy of two methods were calculated respectively and the sensitivity, specificity, accuracy, positive predictive value, negative predictive value of combined application of two methods were also calculated. Results: The accuracy rate and positive predictive value of ⁹⁹Tc^m-MIBI imaging combined with serum tumor markers were higher than that of alone detection(P < 0.05). The specificity of the combination detection was higher than that of tumor marker detection(P < 0.05). There was no significantly difference on the specificity between combination detection and ⁹⁹Tc^m-MIBI imaging(P > 0.05). The sensitivity, negative predictive value among combination, ⁹⁹Tc^m-MIBI imaging and tumor marker detection had no significance difference(P > 0.05). Conclusion: ⁹⁹Tc^m-MIBI imaging combined with serum tumor markers has great clinical significance in identifying pulmonary nodules. (authors)