Published November 1984 | Version v1
Journal article Metadata-only

Preparation of a 211At-IgG conjugate which is stable in vivo

Creators

  • 1. Medical Research Council, Harwell (UK). Radiobiological Research Unit

Description

The short lived (tsub(1/2) 7.2 h) α-particle emitting halogen 211At has been attached to an antibody by using an acylation reaction to conjugate para-[211At]astato-benzoic acid with rabbit IgG. The conjugate, which is stable in vivo, contains at least 30% of the initial activity of 211At. (author)

Additional details

Publishing Information

Journal Title
Int. J. Appl. Radiat. Isot.
Journal Volume
35
Journal Issue
11
Series
Int. J. Appl. Radiat. Isot.
Journal Page Range
1005-1008
ISSN
0020-708X

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
16023625
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACYLATION; ASTATINE 211; BENZOIC ACID; BLOOD-PLASMA CLEARANCE; CHEMICAL PREPARATION; IMMUNOGLOBULINS; INTRAVENOUS INJECTION; LIQUID COLUMN CHROMATOGRAPHY; MICE; MONOCLONAL ANTIBODIES; RABBITS; RADIOACTIVITY; RADIOPHARMACEUTICALS
Descriptors DEC
ALPHA DECAY RADIOISOTOPES; ANIMALS; ANTIBODIES; ASTATINE ISOTOPES; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; CHROMATOGRAPHY; CLEARANCE; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; GLOBULINS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INJECTION; INTAKE; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MONOCARBOXYLIC ACIDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RODENTS; SEPARATION PROCESSES; SYNTHESIS; VERTEBRATES