Structural, thermal and biological activity of curcumin encapsulated casein nanoparticles

The poor water solubility and bioactivity of drugs can be potentially improved by using suitable nanocarriers. In this study, an economically viable methodology is developed for encapsulation of hydrophobic anticancer agent, curcumin in casein nanoparticles (CasNPs). The successful encapsulation of curcumin was evident from the structural, thermal and spectroscopic analysis of curcumin encapsulated CasNPs (Cur-CasNPs). It shows good water-dispersibility, enhanced bioavailability and pH dependent charge conversal feature. Cur-CasNPs showed pH dependent release characteristics with higher at mild acidic environment and enhanced toxicity towards cancer cells (MCF-7) as compared to pure drug, which is desirable for cancer therapy. (author)