Cytomorphological and histomorphological alterations of Jensen sarcoma under cisplatin, radiotherapy, and combined therapy

Puncture cytological and histomorphological results are presented from transplanted Jensen sarcoma. The tested tumors did not respond to therapy in growth reaction and reached a quarter of the body mass of the experimental animals on day 18 post transplantationem. Within the five groups (untreated, cisplatin daily 0.6 mg/kg b.w., irradiated with 2 Gy S.D., 20 Gy T.D. only, and 2 groups combined therapy cisplatin and irradiation) cytological differences were shown between the several therapeutic groups already on therapy day 7 in spite of similar growth reaction, but not between centre and periphery of tumors, that were marked more distinctly and confirmed in histomorphological picture at the end of therapy (day 18). The increased occurence of giant cells with many nuclei and leukocytic inflammation reaction seem to be a typical picture of combined therapy. (author)