Published 1985 | Version v1
Book Metadata-only

HPLC assay for ethiofos in plasma: Application to pharmacokinetics in the beagle dog

Creators

  • 1. Southwest Research Institute, San Antonio, TX 78284 (USA)

Description

An HPLC assay for ethiofos [S-2-(3-amino-propylamino)ethyl phosphorothioate, WR 2727] in plasma is presented. Its application to the development of pharmacokinetic parameters following IV administration of the drug to beagle dogs is demonstrated and preliminary pharmacokinetics of four dosings will be presented. Following a dose of 150 mg kg-1, the plasma concentration versus time profile was best described by a two-compartment pharmacokinetics model. Mean pharmacokinetic parameters were: terminal elimination half-life = 16.0 minutes, volume of central compartment = 129 mL kg-1, and clearance = 11.0 mL min-1 kg-1

Additional details

Publishing Information

Publisher
Radiation Research Society.
Imprint Place
Philadelphia, PA (USA)
Imprint Title
Thirty-third annual meeting of the Radiation Research Society (Abstracts)
Journal Page Range
p. 46.

Conference

Title
33. annual scientific meeting of the Radiation Research Society.
Dates
5-9 May 1985.
Place
Los Angeles, CA (USA).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
19076178
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S61: RADIATION PROTECTION AND DOSIMETRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BEAGLES; BIOLOGICAL EFFECTS; BIOLOGICAL LOCALIZATION; BLOOD PLASMA; CHEMICAL REACTION YIELD; DOSE RATES; HALF-LIFE; INTRAVENOUS INJECTION; KINETICS; METABOLISM; PHOSPHATES; RADIOPROTECTIVE SUBSTANCES; THIOLS
Descriptors DEC
ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BODY FLUIDS; DOGS; DRUGS; INJECTION; INTAKE; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; OXYGEN COMPOUNDS; PHOSPHORUS COMPOUNDS; RESPONSE MODIFYING FACTORS; VERTEBRATES