Published February 2010 | Version v1
Journal article Metadata-only

Note: Application of laser produced plasma Kα x-ray probe in radiation biology

Creators

  • 1. Quantum Beam Science Directorate, Japan Atomic Energy Agency, Advanced Photon Research Center, 8-1-7 Umemidai, Kizugawa, Kyoto 619-0215 (Japan)
  • 2. Department of Medical Physics and Engineering, Graduated School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871 (Japan)
  • 3. Institute of Laser Engineering, Osaka University, 2-6 Yamadaoka, Suita, Osaka 565-0871 (Japan)

Description

A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV in energy x-ray pulses generated with a femtosecond-laser pulse was used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source, thus demonstrating the feasibility of radiobiological studies utilizing a single burst of x-rays focused on single cell specimens.

Additional details

Identifiers

DOI
10.1063/1.3302827;

Publishing Information

Journal Title
Review of Scientific Instruments
Journal Volume
81
Journal Issue
2
Journal Page Range
p. 026107-026107.3
ISSN
0034-6748
CODEN
RSINAK

INIS

Country of Publication
United States
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
44013613
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S70: PLASMA PHYSICS AND FUSION TECHNOLOGY;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; DNA; KEV RANGE; LASER-PRODUCED PLASMA; MEMBRANES; RADIOBIOLOGY; SILICON NITRIDES; STRAND BREAKS; X RADIATION; X-RAY SOURCES
Descriptors DEC
BIOLOGICAL EFFECTS; BIOLOGY; DNA DAMAGES; ELECTROMAGNETIC RADIATION; ENERGY RANGE; IONIZING RADIATIONS; NITRIDES; NITROGEN COMPOUNDS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PLASMA; PNICTIDES; RADIATION EFFECTS; RADIATION SOURCES; RADIATIONS; SILICON COMPOUNDS

Optional Information

Notes
(c) 2010 American Institute of Physics