The role of chemomodifiers in radiation therapy for local breast cancer

The authors describe the association of treatmnt efficacy in breast cancer (BC) both with the use of methods of early tumor detection and multimodality therapy improvement. To increase the tumor damage with ionizing radiation and reduce radioresistance of the malignant cells, various physical and chemical methods, i.e. modifiers, are used. Simultaneous application of several modulation techniques (polymodification) is frequently used. The study involved 75 patients with BC. The patients from the main group (34 persons) were administered radiation therapy against a background of cytostatic drug (Phthorafur) administration in modifying doses and inductothermy. The controls (41 patients) were administered radiotherapy only. Significant increase of the tumor regression at local BC was demonstrated when radiotherapy was delivered against a background of modifiers administration. Local and general reactions did not exceed grade II according to RTOG/EORTC, 1995.