Published February 2014 | Version v1
Journal article Metadata-only

Targeted therapies and companion biomarkers in metastatic prostate cancer

Creators

  • 1. Service d'oncologie medicale, hopital europeen Georges-Pompidou, universite Paris V-Rene-Descartes, 20, rue Leblanc, 75015 Paris (France)

Description

Treatment of castration-resistant prostate cancer has undergone a revolution over the past 3 years with the approval of five new therapies, including new hormonal therapies (abiraterone and enzalutamide) and bone-targeted agents (denosumab, radium-223). New targeted agents have improved survival and quality of life. Currently, companion biomarkers are lacking for a better individualization of treatment. (authors)

Availability note (English)

Available from doi: http://dx.doi.org/10.1016/j.mednuc.2013.12.004

Abstract (French)

Le traitement du cancer de la prostate resistant a la castration a connu une revolution ces trois dernieres annees avec l'autorisation de mise sur le marche de cinq nouvelles therapeutiques dont des hormonotherapies de nouvelle generation (abiraterone et enzalutamide) et des agents ciblant la proliferation tumorale osseuse (denosumab, radium-223). Les nouveaux agents cibles ont permis une amelioration de la survie et de sa qualite. A l'heure actuelle, les biomarqueurs 'compagnons' predictifs d'efficacite des therapies ciblees manquent pour une meilleure individualisation du traitement. (auteurs)

Additional details

Additional titles

Original title (French)
Therapies ciblees et biomarqueurs compagnons dans les cancers de la prostate metastatiques

Identifiers

DOI
10.1016/j.mednuc.2013.12.004;

Publishing Information

Journal Title
Medecine Nucleaire. Imagerie Fonctionnelle et Metabolique
Journal Volume
38
Journal Issue
no.1
Journal Page Range
p. 31-37
ISSN
0928-1258
CODEN
MNIMEX

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
53085713
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BIOLOGICAL MARKERS; BRACHYTHERAPY; CASTRATION; HORMONES; METASTASES; NEOPLASMS; PROSTATE; QUALITY OF LIFE; RADIUM 223; SKELETON
Descriptors DEC
ALKALINE EARTH ISOTOPES; ALPHA DECAY RADIOISOTOPES; BODY; CARBON 14 DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; EVEN-ODD NUCLEI; GLANDS; HEAVY ION DECAY RADIOISOTOPES; HEAVY NUCLEI; ISOTOPES; MALE GENITALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ORGANS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; RADIUM ISOTOPES; SURGERY; THERAPY

Optional Information

Notes
48 refs.