Experiences with 57Co-labelled bleomycin in tumour diagnosis
Description
57Co-BLM is a tumour-affine substance which has been tested in clinical experiments in more than 100 patients. The main indication for 57Co-BLM tumour scintiscanning is in the diagnosis of liver metastases where the detection limit can be considerably improved, in particular by the subtraction method proposed by Haubold. So far, no other tumour-affine substance has yielded satisfactory results. In contrast to gallium, 57Co is excreted mostly renally; The BLM content of the liver 24 h p.i. is less than 1% of the dose applied. The low background activity thus provides a good chance of locating small liver metastases with the aid of radioactively labelled BLM. (orig./AJ)
Availability note (English)
MF available from INIS under the Report Number.Abstract (German)
57Co-BLM ist eine tumoraffine Substanz, die sich im klinischen Experiment an ueber hundert Patienten bewaehrt hat. Als hauptsaechliche Indikation zur 57Co-BLM-Tumor-Szintigraphie wird die Lebermetastasendiagnostik betrachtet, die insbesondere mit dem von HAUBOLD vorgeschlagenen Substraktionsverfahren eine betraechtliche Steigerung der Nachweisempfindlichkeit erlaubt. Keine andere tumoraffine Substanz hat bisher befriedigende Resultate aufweisen koennen. 57Co wird im Gegensatz zu Gallium ueberwiegend renal ausgeschieden, der BLM-Gehalt der Leber 24 h p.i. liegt unter 1% der applizierten Dosis. Damit sind durch die niedrigere Untergrundaktivitaet guenstige Voraussetzungen gegeben, mit Hilfe von radioaktiv markiertem BLM kleine Lebermetastasen zu erkennen. (orig./AJ)
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Additional details
Additional titles
- Original title (German)
- Erfahrungen mit
Publishing Information
- Imprint Pagination
- 45 p.
- Report number
- INIS-mf--5271
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 10484755
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- BLEOMYCIN; BONE MARROW; COBALT 57; COMPARATIVE EVALUATIONS; DIAGNOSTIC TECHNIQUES; DYNAMIC FUNCTION STUDIES; METASTASES; NEOPLASMS; PATIENTS; RADIOPHARMACEUTICALS; SIDE EFFECTS
- Descriptors DEC
- ANTIBIOTICS; ANTIMITOTIC DRUGS; BETA DECAY RADIOISOTOPES; BODY; COBALT ISOTOPES; DAYS LIVING RADIOISOTOPES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HEMATOPOIETIC SYSTEM; INTERMEDIATE MASS NUCLEI; ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TISSUES